HMM Summary Page: TIGR00026
| Accession | TIGR00026 |
| Name | hi_GC_TIGR00026 |
| Function | deazaflavin-dependent oxidoreductase, nitroreductase family |
| Trusted Cutoff | 46.35 |
| Domain Trusted Cutoff | 46.35 |
| Noise Cutoff | 38.15 |
| Domain Noise Cutoff | 38.15 |
| Isology Type | subfamily |
| HMM Length | 111 |
| Mainrole Category | Unknown function |
| Subrole Category | Enzymes of unknown specificity |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| GO:0070967: coenzyme F420 binding molecular_function | |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:04PM |
| Last Modified | Mar 7 2012 12:54PM |
| Comment | This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. |
| References | SE TIGR DR PFAM; PF04075; DUF385 DR INTERPRO; IPR004378 RN [1] RM PMID:19039139 RT PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. RA Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd RL Science. 2008 Nov 28;322(5906):1392-5. |
| Genome Property | GenProp0002: coenzyme F420 utilization (HMM) |