HMM Summary Page: TIGR00025

FunctionABC transporter efflux protein, DrrB family
Trusted Cutoff146.90
Domain Trusted Cutoff146.90
Noise Cutoff58.60
Domain Noise Cutoff58.60
Isology Typeparalog
HMM Length238
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0006810: transport biological_process
GO:0042626: ATPase activity, coupled to transmembrane movement of substances molecular_function
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.
ReferencesSE TIGR