HMM Summary Page: TIGR00024

Functionputative phosphoesterase
Trusted Cutoff115.20
Domain Trusted Cutoff115.20
Noise Cutoff70.20
Domain Noise Cutoff70.20
Isology Typehypoth_equivalog
EC Number3.1.-.-
HMM Length224
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorHaft DH, Richardson DL
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11. SbcD is a subunit of the SbcCD nuclease of E. coli that can cleave DNA hairpins to unblock stalled DNA replication. All members of this family are archaeal.
ReferencesA2 hmmalign SE TIGR GA hmmls RM 9653124 RT The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA. RA Connelly JC, Kirkham LA, Leach DR. RL Proc Natl Acad Sci U S A 1998 Jul 7;95(14):7969-74