HMM Summary Page: TIGR00020

Functionpeptide chain release factor 2
Gene SymbolprfB
Trusted Cutoff383.15
Domain Trusted Cutoff383.15
Noise Cutoff337.40
Domain Noise Cutoff337.40
Isology Typeequivalog
HMM Length365
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003747: translation release factor activity molecular_function
GO:0006415: translational termination biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a PFAM HMM called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc.
ReferencesSE TIGR GA hmmsw DR HAMAP; MF_00094; 133 of 135
Genome PropertyGenProp0746: translation termination, bacterial (HMM)