HMM Summary Page: TIGR00017

Functioncytidylate kinase
Gene Symbolcmk
Trusted Cutoff135.55
Domain Trusted Cutoff135.55
Noise Cutoff36.35
Domain Noise Cutoff36.35
Isology Typeequivalog
EC Number2.7.4.14
HMM Length217
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryNucleotide and nucleoside interconversions
Gene Ontology TermGO:0004127: cytidylate kinase activity molecular_function
GO:0015949: nucleobase-containing small molecule interconversion biological_process
AuthorRichardson DL
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors.
ReferencesSE TIGR AL clustalw RN [1] RM PMID: 9862805 RT Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity RA Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O. RL Structure. 1998 Dec 15;6(12):1517-27 DR HAMAP; MF_01349; 27 of 27