| Accession | TIGR00016 |
| Name | ackA |
| Function | acetate kinase |
| Gene Symbol | ackA |
| Trusted Cutoff | 293.40 |
| Domain Trusted Cutoff | 293.40 |
| Noise Cutoff | 146.10 |
| Domain Noise Cutoff | 146.10 |
| Isology Type | equivalog |
| EC Number | 2.7.2.1 |
| HMM Length | 405 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Fermentation |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0006083: acetate metabolic process biological_process |
| | GO:0006113: fermentation biological_process |
| | GO:0008776: acetate kinase activity molecular_function |
| Author | Richardson DL |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. |
| References | DR PROSITE; PDOC00826;
RN [1]
RM 9484901
RT Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.
RA Hesslinger C, Fairhurst SA, Sawers G.
RL Mol Microbiol. 1998 Jan;27(2):477-92.
DR HAMAP; MF_00020; 241 of 243 |
| Genome Property | GenProp0478: acetyl-CoA -- acetate interconversion via acetyl phosphate (HMM) |
| | GenProp0754: acetate production from acetylphosphate (HMM) |
