HMM Summary Page: TIGR00011

FunctionCys-tRNA(Pro) deacylase
Gene SymbolybaK
Trusted Cutoff153.25
Domain Trusted Cutoff153.25
Noise Cutoff70.15
Domain Noise Cutoff70.15
Isology Typehypoth_equivalog
EC Number3.6.1.-
HMM Length152
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedAug 12 2012 7:41PM
CommentThis HMM represents the YbaK family, bacterial proteins whose full length sequence is homologous to an insertion domain in proline--tRNA ligases. The domain deacylates mischarged tRNAs. The YbaK protein of Haemophilus influenzae (HI1434) likewise deacylates Ala-tRNA(Pro), but not the correctly charged Pro-tRNA(Pro). A crystallographic study of HI1434 suggests a nucleotide binding function. Previously, a member of this family was described as EbsC and was thought to be involved in cell wall metabolism.
ReferencesDR PFAM; PF04073 RN [1] RM PMID:16087664 RT Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex. RA An S, Musier-Forsyth K RL J Biol Chem. 2005 Oct 14;280(41):34465-72. Epub 2005 Aug 8. RN [2] RM 14530268 RT An isolated class II aminoacyl-tRNA synthetase insertion domain is functional in amino acid editing. RA Wong FC, Beuning PJ, Silvers C, Musier-Forsyth K. RL J Biol Chem. 2003 Dec 26;278(52):52857-64. RN [3] RM 10813833 RT Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications. RA Zhang H, Huang K, Li Z, Banerjei L, Fisher KE, Grishin NV, Eisenstein E, Herzberg O RL Proteins 2000 Jul 1;40(1):86-97