| Accession | TIGR00007 |
| Name | TIGR00007 |
| Function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase |
| Gene Symbol | hisA |
| Trusted Cutoff | 228.95 |
| Domain Trusted Cutoff | 228.95 |
| Noise Cutoff | 163.05 |
| Domain Noise Cutoff | 163.05 |
| Isology Type | equivalog |
| EC Number | 5.3.1.16 |
| HMM Length | 231 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Histidine family |
| Gene Ontology Term | GO:0000105: histidine biosynthetic process biological_process |
| | GO:0003949: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function |
| Author | Richardson DL, Haft DH |
| Entry Date | Feb 22 2000 11:31AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step.
Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity [1]; the trusted cutoff here has now been raised to 275.0 to exclude the bifunctional group, now represented by model TIGR01919. HisA from Lactococcus lactis was reported to be inactive (MEDLINE:93322317). |
| References | SE TIGR
AL clustalw
DR ECOCYC; EG10444; hisA
DR EXPERIMENTAL; SP|P05325; Methanococcus voltae
DR EXPERIMENTAL; GB|AAC75085.1; Escherichia coli
RN [1]
RM PMID: 12634849
RT Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis.
RA Baroma-Gomez F., Hodgson, DA
RL EMBO Rep. 2003 Mar; 4(3): 296-300
DR HAMAP; MF_01014; 382 of 447 |
| Genome Property | GenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM) |
