HMM Summary Page: TIGR00007

Function1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
Gene SymbolhisA
Trusted Cutoff228.95
Domain Trusted Cutoff228.95
Noise Cutoff163.05
Domain Noise Cutoff163.05
Isology Typeequivalog
EC Number5.3.1.16
HMM Length231
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryHistidine family
Gene Ontology TermGO:0000105: histidine biosynthetic process biological_process
GO:0003949: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function
AuthorRichardson DL, Haft DH
Entry DateFeb 22 2000 11:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step. Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity [1]; the trusted cutoff here has now been raised to 275.0 to exclude the bifunctional group, now represented by model TIGR01919. HisA from Lactococcus lactis was reported to be inactive (MEDLINE:93322317).
ReferencesSE TIGR AL clustalw DR ECOCYC; EG10444; hisA DR EXPERIMENTAL; SP|P05325; Methanococcus voltae DR EXPERIMENTAL; GB|AAC75085.1; Escherichia coli RN [1] RM PMID: 12634849 RT Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis. RA Baroma-Gomez F., Hodgson, DA RL EMBO Rep. 2003 Mar; 4(3): 296-300 DR HAMAP; MF_01014; 382 of 447
Genome PropertyGenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)