HMM Summary Page: TIGR00006

Function16S rRNA (cytosine(1402)-N(4))-methyltransferase
Gene SymbolrsmH
Trusted Cutoff154.30
Domain Trusted Cutoff154.30
Noise Cutoff114.95
Domain Noise Cutoff114.95
Isology Typeequivalog
EC Number2.1.1.199
HMM Length310
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008168: methyltransferase activity molecular_function
GO:0009252: peptidoglycan biosynthetic process biological_process
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedAug 12 2012 7:26PM
CommentThis HMM describes RsmH, a 16S rRNA methyltransferase. Previously, this gene was designated MraW, known to be essential in E. coli and widely conserved in bacteria.
ReferencesRN [1] RM PMID:22561317 RT Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. RA Wei Y, Zhang H, Gao ZQ, Wang WJ, Shtykova EV, Xu JH, Liu QS, Dong YH RL J Struct Biol. 2012 Jul;179(1):29-40. Epub 2012 Apr 27. RN [2] RM PMID:10572301 RT mraW, an essential gene at the dcw cluster of Escherichia coli codes for a cytoplasmic protein with methyltransferase activity. RA Carrion M, Gomez MJ, Merchante-Schubert R, Dongarra S, Ayala JA RL Biochimie. 1999 Aug-Sep;81(8-9):879-88. RN [2] RM PMID:4563986 RT Cell wall peptidoglycan mutants of Escherichia coli K-12: existence of two clusters of genes, mra and mrb, for cell wall peptidoglycan biosynthesis. RA Miyakawa T, Matsuzawa H, Matsuhashi M, Sugino Y RL J Bacteriol. 1972 Nov;112(2):950-8. DR HAMAP; MF_01007; 272 of 272
Genome PropertyGenProp1082: 16S rRNA C1402 m(4)Cm modification (HMM)
GenProp0802: ribosome biogenesis proteins, bacteria (HMM)